D-Fix PFS
Cefixime 100 mg/5ml
D-Fix PFS
Cefixime 100 mg/5ml
Description
D-Fix (Cefixime) is a broad-spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic and is stable for hydrolysis by many beta-lactamases. D-Fix kills bacteria by interfering in the synthesis of the bacterial cell wall. D-Fix is highly active against Neisseria gonorrheae, Haemophilus influenzae, Moraxella catarrhalis including beta lactamase producers, most of the Enterobacteriaceae, beta-hemolytic Streptococcus (group A & B) and Streptococcus pneumoniae. D-Fix is more active than other oral cephalosporin against Escherichia coli, Klebsiella species, Proteus mirabilis and Serratia marcescens. D-Fix is also active against Streptococcus pyogenes. 40-50% of an oral dose is absorbed from gastrointestinal tract, whether taken with meals or not. The plasma half life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% of D-Fix in the circulation is bound to plasma protein. D-Fix is mainly excreted unchanged in bile and urine.
- AVAILABILITY: AVAILABLE
Composition
D-Fix Powder For Suspension: After reconstitution each 5ml suspension contains Cefixime BP 100 mg.
Indication
Upper and lower respiratory tract infections
Urinary tract infections
Gonococcal urethritis
Acute otitis media
Dosage and administration
200 mg or 400 mg daily for 7-14 days, according to the severity of the infection.
Side-effects
D-Fix is generally well tolerated. The majority of adverse reactions observed in clinical trials were mild and self-limiting in nature.
Gastrointestinal disturbances: Diarrhea (if severe diarrhea occurs D-Fix should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence, have been reported.
Central nervous system disturbances: Headache, dizziness.
Others: Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.
Contraindication
Patients with known hypersensitivity to cephalosporin group of antibiotics.
Precaution
D-Fix should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure.
In pregnancy and lactation
No data are available, so it is probably best to avoid using the drug during pregnancy and by the nursing mothers.
Drug interaction
No data are available.
Pharmaceutical precaution
Store in a cool, dry place and protect from light and moisture. Keep out of reach of children.
Packing
D-Fix Powder for Suspension: Bottle containing dry granules to reconstitute 50ml & 30ml Suspension.