Uses 
Depol Extra is a combined preparation of Paracetamol and Caffeine. Paracetamol has analgesic, and antipyretic properties with week anti inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and 
headache.
 
Depol Extra is indicated for the relief of fever, migraine and headache, common colds and flu, sore throat, earache, toothache, backache, rheumatic and muscular pain, neuralgia and period pain. 

Dosage and administration 
Depol Extra is suitable for adults and adolescents over 12 years of age as 1-2 tablets in every 4 hours as needed. Maximum dose is 8 tablets in 24 hours. 
It is not recommended for children under 12 years of age. 

Contraindication 
It is contraindicated in patients with known hypersensitivity to paracetamol, Caffeine or any other component of it. 

Side effects 
In recommended doses, it is usually free from side effects. However, skin reactions such as urticaria have been reported rarely. 

Precaution 
It should be used with caution in severe liver or kidney damage. Other Paracetamol containing medications should not be taken at the same time. Avoid drinking too much coffee or tee when taking the preparation. 

Drug interaction 
It may interact with anticoagulants on prothrombin time. The liver effects of it may be increased by the use of alcohol and concomitant use of certain drugs which enhance the metabolism of Paracetamol in the liver (i.e., barbiturates, tricyclic antidepressants). 

Use in pregnancy and lactation 
Although there is epidemiological evidence of the safety of Paracetamol in pregnancy and lactation, medical advice should be sought before using this product. 

Pharmaceutical precaution 
Store in a cool, dry place and protect from light below 300 C. Keep out of reach of children. 

Packing 
Depol Extra Tablet : Box containing 10 x10/20 x10 tablets in blister pack.