Indications
Lansoprazole is shown for: Short term treatment of dynamic duodenal ulcer Maintenance of mended duodenal ulcers Short term treatment of dynamic generous gastric ulcers Short term treatment of dynamic erosive esophagitis Maintenance of recuperating of erosive esophagitis Pathological hypersecretory conditions counting Zollinger- Ellison Syndrome H. pylori destruction to diminish the chance of duodenal ulcer repeat

Pharmacology
Lansoprazole may be a substituted benzimidazole, and is additionally known as PPI due to its property to piece the ultimate step of corrosive emission by restraining H+/K+ ATPase protein framework in gastric parietal cell. Both basal and invigorated corrosive are hindered.

Dosage & Administration
Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.
Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.
NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.
Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.
Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.
Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

Interaction
Lansoprazole shows up to be a specific inhibitor of the cytochrome P-450 monooxygenase framework; there may be an impact on hepatic clearance, but there have been no reports to date of clinically important intuitive. There's a few instability over the impact of Lansoprazole on the verbal combined prophylactic pill. Assist appraisal is right now underway. Physiological changes comparable to those found with Omeprazole are likely to require put since of the decrease in gastric corrosive, which is likely to impact the bacterial colonization of the stomach and duodenum additionally vitamin B12 retention.

Contraindications
Lansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects
Extreme or irreversible unfavorable impacts: The conceivable acceptance of carcinoid tumors by significant corrosive concealment, and a rise in serum gastrin may happen. There's a rise in serum gastrin levels within the to begin with 3 months of treatment, which are at that point kept up in spite of the fact that at a lower level than those found in malignant weakness. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori disease may quicken the improvement of atrophic gastritis. Symptomatic antagonistic impact: Measurements subordinate loose bowels happens with an frequency of approximately 4% at 30 mg per day, rising to 8% at 60 mg per day. Migraine happens in 2-3% of treated patients

Pregnancy & Lactation
Lansoprazole ought to be maintained a strategic distance from in pregnancy unless there are compelling reasons.

Precautions & Warnings
Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.

Therapeutic Class
Proton Pump Inhibitor

Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.