D-Fix 400

Cefixime BP 400mg


D-Fix 400 Capsule: Each Capsule contains Cefixime Trihydrate BP equivalent to Cefixime BP 400 mg.


D-Fix (Cefixime) is a broad spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many beta lactamase. D-Fix kills bacteria by interfering in the synthesis of the bacterial cell wall. D-Fix is highly active against Neisseria gonorrheae, Haemophilus influenzae, Moraxella catarrhalis including beta lactamase producers, most of the Enterobacteriaceae, beta hemolytic Streptococcus (group A & B) and Streptococcus pneumoniae. D-Fix is more active than other oral cephalosporin against Escherichia coli, Klebsiella species, Proteus mirabilis and Serratia marcescens. D-Fix is also active against Streptococcus pyogenes. 40-50% of an oral dose is absorbed from gastrointestinal tract, whether taken with meals or not. The plasma half life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% of D-Fix in the circulation is bound to plasma protein. D-Fix is mainly excreted unchanged in bile and urine.  

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Upper and lower respiratory tract infections

Urinary tract infections

Gonococcal urethritis                                                            

Acute otitis media

Dosage and administration

200 mg or 400 mg daily for 7-14 days, according to the severity of the infection.


D-Fix is generally well tolerated. The majority of adverse reactions observed in clinical trials were mild and self-limiting in nature.

Gastrointestinal disturbances: Diarrhea (if severe diarrhea occurs D-Fix should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence, have been reported.

Central nervous system disturbances: Headache, dizziness.

Others: Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.


Patients with known hypersensitivity to cephalosporin group of antibiotics.


D-Fix should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure.

In pregnancy and lactation

No data are available, so it is probably best to avoid using the drug during pregnancy and by the nursing mothers.

Drug interaction

No data are available.

Pharmaceutical precaution

Store in a cool, dry place and protect from light and moisture. Keep out of reach of children.


D-Fix 400 Capsule: Box containing 2´4/3´4/4´5/5´6 capsules in alu-alu blister pack.