Kufflin Syrup

Ambroxol Hydrochiloride BP


Kufflin Syrup: Each 5 ml syrup contains Ambroxol Hydrochloride BP 15 mg.


Ambroxol is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecrolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism leading to liquefaction of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyper-reactivity. Ambroxol has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.

Share on Social Media:


It is indicated in following cases:

  • Productive cough.
  • Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis.
  • Inflammatory diseases of rhinopharyngeal tract (e.g. laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus.
  • Asthmatic bronchitis, bronchial asthma with thick expectoration.
  • Bronchiectasis.
  • Chronic pneumonia.

Dosage and administration

The following dosage is recommended:

2-5 years old: 2.5 ml (1/2 teaspoonful), 2-3 times daily preferably after meal.

5-10 years old: 5 ml (1 teaspoonful), 2-3 times daily preferably after meal.

Adult & child over 10 years old: 10 ml (two spoonfuls), 3 times a day preferably after meal.


Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

Side effects

Gastrointestinal side effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema have been reported.


Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Drug interaction

Ambroxol should not be taken simultaneously with antitussives (e.g. Codeine) because phlegm, which has been liquefied by Ambroxol, might not be expectorated.

Use in pregnancy and lactation

Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the first trimester. Safety during lactation has not been established yet.

Pharmaceutical precaution

Store in a cool, dry place and protect from direct light exposure. Keep out of reach of children.


Kufflin Syrup: Transparent plastic bottle containing 100 ml syrup.